GLP-1s Effective for Migraine Management?

GLP-1 receptor agonists may have a role in chronic migraine

Using the TriNetX database, Acar and colleagues analyzed health record data from roughly 11,000 people with chronic migraine initiating a GLP-1 receptor agonist and a propensity score-matched group of roughly 11,000 initiating topiramate, a drug commonly used to prevent migraine attacks. Participants had a mean age of 48 years and 88% were women.

They found that those with chronic migraine who started a GLP-1 drug were about 10% less likely to visit the emergency department and 14% less likely to be hospitalized compared with peers who started topiramate.

The GLP-1 users were also about 13% less likely to undergo a nerve block procedure or receive a triptan prescription compared with those taking topiramate.

The researchers said these preliminary observations point to a potential role for GLP-1 receptor agonists in migraine management and warrant prospective evaluation. 

Source: MEDspace