Researchers in Japan showed that a unique neutrophil subset, characterized by type II interferon signature genes (T2ISG), along with elevated levels of interferon gamma in the blood, can predict the risk for relapse in patients with new-onset microscopic polyangiitis (MPA).

Researchers conducted single-cell transcriptome and surface proteome analyses of peripheral white blood cells from patients with new-onset MPA to study neutrophil dynamics in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis.

“Our work elucidates neutrophil dynamics at the single-cell level and suggests a potential biomarker for predicting relapse in MPA,” the authors of the study wrote.

Source: MEDspace