(LEAFLET)

FOOD SUPPLEMENT

SANTIGEN

Prebiotic and probiotic

for regulation of microflora of the gastrointestinal tract

INSTRUCTION FOR USE

Composition: 1 sachet contains:

Lactobacillus sporogenes (Bacillus coagulans) – 50 x 10⁶ CFU

Streptococcus faecalis (Enterococcus faecalis) – 30 x 10⁶ CFU

Clostridium butyricum – 2 x 10⁶ CFU

Bacillus mesentericus – 1 x 10⁶ CFU

Excipients: lactose anhydrous, colloidal silicon dioxide anti‐caking agent.

Characteristics of ingredients:

Lactobacillus sporogenes (Bacillus coagulans) is a spore-forming bacterium that supports the growth of beneficial bacteria and inhibits the growth of pathogens, thereby maintaining a healthy balance of intestinal microflora.

Lactobacillus sporogenes exhibits an immunostimulating effect. It is capable to improve human immunity due to the production of immunoglobulin M, G and A.

Spores of Lactobacillus sporogenes are acid-resistant.  They ripen and multiply when getting into the intestines. The spores produce lactic acid, which penetrates membranes and reduces the intracellular pH level in pathogens. This results in disruption of metabolic processes and leads to the death of pathogens. Also, the spores produce bacteriocins (substances that can damage the pathogens’ membrane), which exhibit an antimicrobial activity. By participating in the breakdown of proteins and carbohydrates, Lactobacillus sporogenes contributes to the normalization of digestion.

Streptococcus faecalis is a gram-positive bacterium that is a representative of the normal intestinal microflora. Streptococcus faecalis belongs to Enterococcus spp., therefore, as a representative of this spices, it is able to prevent adhesion and reproduction of pathogens on the intestinal mucosa. Streptococcus faecalis is resistant to beta-lactam antibiotics and aminoglycosides, so it can be used with antibiotics.

Bacillus mesentericus is a spore-forming bacterium that inhibits the growth of pathogens, such as Staphylococcus aureus, Staphylococcus albus, Corynebacterium diphtheriae, Streptococcus viridans, Bacillus anthracis, Klebsiella pneumoniae, Salmonella typhi. Bacillus mesentericus is involved in the enzyme amylase synthesis, which contributes to the digestion and carbohydrates absorption.

Streptococcus faecalis (Enterococcus faecalis), Bacillus mesentericus contribute to a significant increase in the number of lacto- and bifidobacteria in the intestine. Clostridium butyricum is a spore-forming bacterium that is effective against the pathogenic bacteria - Clostridium difficile. It helps to reduce the pathogenic bacteria reproduction. Clostridium butyricum produces short-chain fatty acids such as butyric acid and acetic acid, thereby reducing the pH in the intestine and, as a consequence, the growth of pathogens. In addition, Clostridium butyricum contributes to the regulation of intestinal function.

Recommendations for use: the complex can be recommended as an additional source of prebiotics and probiotics that contribute to:

• restoration of eco-balance of the intestinal microflora;
• prevention of the intestinal microflora disorders caused by antibiotics (antibiotic-associated diarrhea);
• normalisation of the condition in gastrointestinal tract disorders associated with gastrointestinal infections;
• normalisation of the digestion by producing digestive enzymes;
• strengthening of the body health by improving immunity against bacterial infections.

It is recommended to consult your doctor before use.

Warnings: Do not to exceed the recommended daily dose (serving). The product is not a substitute for a balanced diet.

Contraindications: the product is contraindicated for pregnant and breastfeeding women, children under 3 years of age and people with individual hypersensitivity to any of the components.

Method of administration: the contents of each sachet should be dissolved in a sufficient amount of water (20-100 ml per sachet) and orally taken with or without food.

Dosage: Santigen is recommended for adults and children over 3 years of age. Adults and children over 12 years of age should take 1 sachet 3-4 times a day.

Children aged 6 - 12 years should take 1 sachet twice a day.

Children aged 3 - 6 years should take 1 sachet once a day.

Duration of use: 7 to 14 days or as per doctor’s prescription. If necessary, the course of Santigen can be repeated.

Release form: 1 g sachet powder, 20 sachets in a packaging.

Storage conditions: store in a place protected from light at a temperature not exceeding 25 °C in the original manufacturer’s packaging.

Keep out of reach of children.

Shelf life: 2 years from the date of manufacture.

Food supplement. It is not a medicinal preparation.

Does not contain GMO.

Manufacturer: Ananta Medicare Limited, legal address: 621, Ring Road Mall, Sector-3, Rohini, New Delhi – 110085, India, tel.: +91 1147050531.

Actual manufacturing (site) facility address: G-1-265, Phase-II, RIICO Industrial Area, Udyog Vihar, Sri Ganganagar (Raj), India.

Importer/Organization receiving consumer complaints: Evitas Ltd.,

37, Iskrinska str., Kharkiv, 61001, Ukraine, tel./fax: +38 (057) 766-07-44.